What is Trimix Erectile Dysfunction (ED) Medication?
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Injectable Option for Erectile Dysfunction
Not all men respond positively to commercially available erectile dysfunction (ED) pills like Viagra or Cialis. When those medications don’t cut it, what are other options that men turn to?
According to the University of Utah, injectable solutions for ED has gained acceptance globally since 1985, helping many men get their sex lives back.
What is Trimix Erectile Dysfunction Medication?
Trimix is an injectable medication made up of three drugs (prostaglandin, papaverine, and phentolamine) which is a potent mix used to address erectile dysfunction. The three drugs work synergistically.

Papaverine is a vasodilator or a drug that expands the blood vessels. It helps to cause an erection by allowing an increased flow of blood to the penis.
Phentolamine relaxes and dilates the blood vessels thus inducing an erection, as well as increasing cardiac output.
Prostaglandin is a potent hormone-like substance that induces erections by relaxing the penis’s blood vessels, allowing for more blood into the penis and less blood out.
Trimix requires a prescription, and as a compounded medication, the dosage is tailored to meet the needs of the individual as specified by the medical provider. Prescriptions can be adjusted to meet specific needs, and additional medications such as atropine can be added as necessary.
The Pharmacists at Community Clinical Pharmacy developed a method to freeze-dry TriMix ingredients (Prostaglandin, Papaverine, Phentolamine) without compromising the active ingredients or strength.
For a more general discussion of ED solutions, see here:
Addressing Erectile Dysfunction: Compounded Solutions and More
How is Trimix Administered?
The medication is administered via intracavernosal injection (between the side and the base of the penis).
For a deeper discussion on the subject of erectile dysfunction, ask one of our expert pharmacists.
For medical providers, get in touch with us to see how this may help your patients.
Cautionary Information
Temporary swelling of the skin of the penis — this occurs when the needle isn’t placed properly.
Bleeding on the injection site — this appears as a black or blue patch on the site that disappears after a few days. This occurs either when a vein is punctured or when insufficient pressure is applied to the injection site after administration.
Prolonged erection or priapism — this is when the erection lasts for hours and could be a potentially serious complication that, if ignored, can lead to permanent impotence.

If there is no response from the medication, it may be from:
- Inadequate dose
- Incorrect administration
- Expired medication
- Infection
- Scarring or deformity of the penis
When you are considering Trimix or any other injectable for Erectile Dysfunction (ED), it’s important that you consult with your doctor and fill your prescription with a compounding pharmacy that specializes in formulating Trimix, like Community Clinical Pharmacy. Contact our expert pharmacists or schedule a consultation for the best Trimix compounding in Arizona.
When in doubt, contact one of our knowledgeable pharmacists at Community Clinical Pharmacy. We are here to offer you solutions and assist you in making informed decisions about your health. Contact us with comments, questions, or pharmacy related topics you’d like to know more about. And, as always, stay healthy!
Here to Help
If you have any questions, or would like to learn more about your options when it comes to hormone replacement, please call Community Clinical Pharmacy and we can consult with you and your physician to find the best solution.
We serve the East Valley Metro Area including Mesa, Chandler, Gilbert, and surrounding areas.
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